|
KMID : 0603820080140010055
|
|
Journal of Experimental & Biomedical Science
2008 Volume.14 No. 1 p.55 ~ p.58
|
|
|
Association of Clusterin Polymorphisms with Coronary Heart Disease in Koreans
|
|
Kim Jun-Young
Kim Su-Won
Lee In-Kyu
Yoo Min
|
|
|
Abstract
|
|
|
|
Clusterin is an 80 kDa heterodimetric glycosylated protein and it plays diverse biological roles in various tissues and organs. Clusterin is reported to be associated with the pathogenesis of coronary artery disease and atherosclerosis. Therefore, we investigated the genotype for the A/G polymorphism at the position 4,183 of clusterin gene in Koreans and compared genotype of patients with control group. 100 patients (Male 63, Female 37), who previously underwent coronary artery stent due to ischemic heart disease and 100 controls (Male 36, Female 64) participated in this study. There was a significant association between 4,183 A/G polymorphism in clusterin gene and coronary artery disease (CAD). The present study shows that clusterin gene A/G polymorphism may be associated with the pathogenesis of CAD. Further studies with larger population may be needed for the development of diagnostic methods at genetic level such as DNA chip.
|
|
|
KEYWORD
|
|
|
Clusterin gene, Polymorphism, Type 2 Diabetes, Korean
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|